Can I take Solifenacin and Vitamin B2 together?

Why this happens

Solifenacin is processed by the liver (specifically the CYP3A4 enzyme), while vitamin B2 is a water-soluble vitamin absorbed in the small intestine and excreted by the kidneys. They do not share the same metabolic pathways or affect each other's absorption or action in the body.

You can continue taking both as prescribed or recommended. As with any supplement, it is best to take vitamin B2 with food to help absorption, whereas solifenacin can be taken with or without food.

Glaucoma

Do not take solifenacin if you have narrow-angle glaucoma, as it can increase the pressure in your eyes and worsen the condition.

Urinary retention

Do not take solifenacin if you have difficulty emptying your bladder (urinary retention), as it may make this problem worse.

Urine colour change

Vitamin B2 will turn your urine a bright yellow or orange colour. This is harmless and expected, but it is important to be aware of it so you are not alarmed.

Alcohol

It is best to avoid or strictly limit alcohol while taking solifenacin. Both alcohol and solifenacin can cause drowsiness and blurred vision; combining them increases the risk of these side effects and may impair your coordination.

It is best to avoid or strictly limit alcohol when taking Vitamin B2. Alcohol can interfere with the way your body absorbs this vitamin from the digestive tract, making the supplement less effective.

Grapefruit Juice

Grapefruit juice can increase the level of solifenacin in your blood, which may increase the risk of side effects such as dry mouth, constipation, and blurred vision. It is best to avoid drinking large amounts of grapefruit juice.

Caffeine (Coffee, Tea, Energy Drinks)

You should limit your intake of caffeine. Solifenacin is used to treat an overactive bladder, but caffeine is a natural diuretic and bladder irritant that can worsen symptoms like urgency and frequency, potentially making your medication less effective.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.