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Can I take Pregabalin and Quinine together?

Guía de interacción de medicamentos

Taking pregabalin and quinine together can increase the risk of side effects that affect your brain and nervous system. You may feel more sleepy, dizzy, or confused than usual. There is also a small risk that both medications could affect your heart rhythm or increase the chance of having a seizure, especially if you are already prone to them.

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Por qué sucede esto

Both drugs can slow down the central nervous system (additive effect). Additionally, while they work in different ways, both medications can influence the electrical activity in the heart and brain. Quinine can occasionally interfere with how other drugs are processed in the body, though pregabalin is mostly cleared by the kidneys.

Use this combination with caution. If you feel excessively drowsy, dizzy, or notice a fluttering sensation in your chest (palpitations), contact your doctor. Avoid driving or operating machinery until you are certain the combination does not impair your alertness. It is best to avoid or strictly limit alcohol, as it will make the sleepiness much worse.

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Trastornos de salud mental

La pregabalina puede causar pensamientos suicidas o ganas de autolesionarse. Debe buscar ayuda médica de inmediato si su estado de ánimo cambia o tiene pensamientos de hacerse daño.

Depresión respiratoria severa

La pregabalina puede causar problemas respiratorios graves, especialmente si ya tiene una enfermedad pulmonar o si la toma junto con otros medicamentos sedantes como los opioides. Busque ayuda de emergencia si experimenta respiración lenta, superficial o difícil.

Embarazo

El uso de pregabalina durante los primeros tres meses de embarazo puede aumentar el riesgo de defectos de nacimiento. Se debe utilizar anticoncepción efectiva durante el tratamiento.

Dependencia de drogas y abstinencia

Pregabalin carries a risk of dependence and addiction. Do not stop taking it suddenly, as this can cause severe withdrawal symptoms such as seizures or anxiety.

Trastornos del ritmo cardíaco (Síndrome de QT largo)

Quinine can cause serious, potentially life-threatening heart rhythm problems. Do not take this if you have a history of 'Long QT syndrome' or an irregular heartbeat.

Tinnitus (ringing in the ears) or optic neuritis

Stop taking quinine immediately and seek medical advice if you experience any changes to your hearing (such as ringing) or any sudden changes to your vision.

Thrombocytopenia (low blood platelets)

Quinine can cause a dangerous drop in blood platelets. Seek urgent medical help if you notice unexplained bruising, nosebleeds, or purple spots on your skin.

Alcohol

It is best to avoid or strictly limit alcohol while taking pregabalin. Combining alcohol with this medicine can significantly increase side effects such as extreme sleepiness, dizziness, and blurred vision. It can also increase the risk of breathing problems.

Jugo de toronja

Avoid drinking grapefruit juice or eating grapefruit while taking quinine. Grapefruit contains compounds that can increase the level of quinine in your blood, which significantly raises the risk of serious side effects, including heart rhythm problems.

Tonic water

Tonic water contains small amounts of quinine. While the levels are low, consuming large amounts of tonic water alongside your medication could potentially increase the risk of side effects.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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