Can I take Melatonin and Red vine leaf extract together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no known direct interaction between melatonin and red vine leaf extract. However, both substances can occasionally affect blood pressure or blood thinning, which could theoretically lead to a combined effect.
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Why this happens
Melatonin is a hormone used for sleep, and red vine leaf extract is a herbal supplement used for circulation (venous insufficiency). While they work differently, both have minor effects on blood vessel tone. Red vine leaf contains flavonoids that may have very mild blood-thinning properties, while melatonin can slightly lower blood pressure in some people.
What you should do
Back to contentsIt is generally considered safe to take these together. However, if you are already taking prescribed medication for blood pressure or blood thinning (like warfarin or aspirin), you should consult your doctor or pharmacist before combining these supplements. Monitor yourself for any unusual bruising or dizziness when starting the combination.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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