Can I take Indometacin and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Omeprazole is often prescribed alongside indometacin to protect the stomach. There is no harmful interaction between these two medicines; in fact, omeprazole helps reduce the risk of stomach ulcers and bleeding caused by indometacin.
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Why this happens
Indometacin is a non-steroidal anti-inflammatory drug (NSAID) that can irritate the stomach lining. Omeprazole is a proton pump inhibitor (PPI) that reduces stomach acid, providing a protective effect. There are no significant changes to how the body absorbs or clears either drug when taken together.
What you should do
Back to contentsIt is safe and often recommended to take these together. Always take indometacin with or after food to further protect your stomach.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can trigger a severe or life-threatening asthma attack.
Pregnancy (third trimester)
You must not take this medicine if you are more than 20 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and reduce amniotic fluid.
Stomach ulcers or bleeding
Indometacin significantly increases the risk of stomach ulcers and bleeding; while omeprazole is often prescribed to protect the stomach, you must seek immediate medical help if you pass black, tarry stools or vomit blood.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking indometacin can increase the risk of developing stomach ulcers or bleeding in the digestive tract. It may also increase the risk of drowsiness or dizziness. It is best to limit or avoid alcohol while taking this medicine.
Food (General)
Indometacin should always be taken with or just after food, or with a glass of milk. This helps to protect your stomach lining and reduces the risk of indigestion or stomach upset.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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