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Can I take Indapamide and Losartan together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than intended, especially when you first start the combination. It can also lead to a significant decrease in kidney function and changes in your blood salt levels (specifically potassium).

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Why this happens

Both medicines work to lower blood pressure but in different ways. Indapamide is a 'water tablet' (diuretic) that removes salt and water from the body, while losartan relaxes blood vessels. When used together, they have an additive effect. Additionally, indapamide can lower potassium levels while losartan tends to raise them; while this can sometimes balance out, it can also put strain on the kidneys.

Your doctor will likely monitor your blood pressure and perform regular blood tests to check your kidney function and salt levels. To prevent dizziness, try to stay well-hydrated and get up slowly from a sitting or lying position. Contact your doctor if you feel very dizzy, unusually tired, or if you notice a decrease in how much you urinate.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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