Can I take Cinnarizine and Desloratadine together?

Why this happens

Both cinnarizine and desloratadine are antihistamines. Even though desloratadine is designed to be 'non-drowsy', combining it with another antihistamine like cinnarizine creates an 'additive effect'. This means their sedative properties stack up, making you much more drowsy than taking either one alone.

It is generally best to avoid taking these two medicines at the same time. If you need to treat both travel sickness (cinnarizine) and allergies (desloratadine), speak to your pharmacist about alternative combinations. If you must take both, do not drive, cycle, or operate machinery until you know how the combination affects you, and avoid drinking alcohol as this will make the sleepiness even worse.

Parkinson's disease

Cinnarizine can worsen symptoms like tremors and muscle stiffness, and should be avoided if you have Parkinson's disease.

Severe kidney or liver disease

You may need a lower dose or a different dosing schedule if your kidney or liver function is significantly impaired.

Alcohol

You should avoid drinking alcohol while taking cinnarizine. Cinnarizine can cause drowsiness, and alcohol will significantly increase this effect, making you feel much more sleepy and affecting your coordination.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.