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Can I take Bisoprolol and Eplerenone together?

Drug interaction guide

Taking these two medicines together can cause the level of potassium in your blood to become too high (hyperkalaemia). It can also lead to a significant drop in blood pressure, which might make you feel dizzy or lightheaded.

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Why this happens

Both medicines affect how your body handles minerals and fluids. Eplerenone is a 'potassium-sparing' diuretic that prevents your body from flushing out potassium. Bisoprolol can also cause potassium levels to rise by affecting how it moves in and out of your cells. Additionally, both drugs lower blood pressure, so their combined effect is stronger than taking either one alone.

You can take these medicines together, but your doctor must monitor you closely. You will need regular blood tests to check your potassium levels and kidney function, especially when starting or changing doses. Avoid using salt substitutes that contain potassium (often labelled as 'low sodium' salt) and speak to your doctor if you feel dizzy, have palpitations, or experience muscle weakness.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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