Can I take Aspirin and Synjardy together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking aspirin with Synjardy (which contains metformin and empagliflozin) may increase the risk of low blood sugar (hypoglycaemia). Additionally, high doses of aspirin can increase the risk of a rare but serious condition called lactic acidosis, which is also a potential side effect of the metformin in Synjardy. There is also a risk of kidney strain if both are used long-term.
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Why this happens
Aspirin can enhance the glucose-lowering effects of diabetes medications. Furthermore, both metformin and high-dose aspirin can affect how the body handles acid and kidney function, potentially leading to a buildup of metformin in the blood.
What you should do
Back to contentsUse with caution. If you are taking low-dose aspirin (75mg to 150mg) for heart protection, this is usually fine, but you should monitor your blood sugar levels more closely. Avoid taking high-dose aspirin (for pain relief) without speaking to your doctor first. Seek medical help immediately if you experience extreme tiredness, rapid breathing, or feeling cold and unwell.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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