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Can I take Aspirin and Bisoprolol together?

Drug interaction guide

Taking aspirin and bisoprolol together may slightly reduce the blood-pressure-lowering effect of bisoprolol. Additionally, both medications can be tough on the stomach, potentially increasing the risk of irritation or ulcers.

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Why this happens

Aspirin belongs to a group of medicines called NSAIDs. These can cause the body to retain salt and water and can interfere with natural chemicals (prostaglandins) that help keep blood pressure low. This works against bisoprolol, which is trying to lower your blood pressure. Both drugs can also affect the lining of the stomach.

For most people, these two medicines are safe to take together, especially if the aspirin is a low 'baby' dose (75mg to 150mg) for heart protection. However, you should have your blood pressure checked regularly by your GP or pharmacist. If you notice any stomach pain, indigestion, or black/tarry stools, speak to your doctor immediately.

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Asthma or Chronic Obstructive Pulmonary Disease (COPD)

This medicine can cause severe breathing difficulties and should be avoided if you have a history of asthma or significant lung disease.

Pregnancy (third trimester)

Do not take aspirin during the last three months of pregnancy as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.

Alcohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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