Can I take Amoxicillin and Cresemba together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between amoxicillin and Cresemba (isavuconazole). It is generally considered safe to take these two medications together.
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Why this happens
Amoxicillin is an antibiotic primarily cleared from the body by the kidneys. Cresemba is an antifungal medication processed mainly by the liver. Because they use different pathways for breakdown and removal, they do not interfere with each other's levels in the blood.
What you should do
Back to contentsYou can take both medications as prescribed by your doctor. Always finish the full course of your antibiotic (amoxicillin) even if you feel better. If you experience unusual side effects like a severe skin rash or persistent diarrhoea, contact your healthcare provider.
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Important precautions
Back to contentsPenicillin allergy
Do not take this medicine if you have ever had an immediate allergic reaction (such as a rash, swelling, or breathing difficulties) to any penicillin or cephalosporin antibiotic, as this can lead to a life-threatening reaction.
Short QT syndrome
You must not take this medicine if you have a heart condition called familial Short QT syndrome, as it can cause dangerous heart rhythm disturbances.
Severe liver disease
This medicine can cause severe liver injury; you must report any yellowing of the skin or eyes, or severe upper stomach pain immediately.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the levels of this medicine in your blood, which may increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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