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Can I take Amlodopine and Losartan together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than if you took either one alone. While this is often the goal of treatment, it can sometimes lead to symptoms like dizziness, lightheadedness, or fainting, especially when you stand up quickly. There is also a small risk of affecting your kidney function or increasing potassium levels in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the blood vessels directly, while losartan blocks a hormone (angiotensin II) that normally makes blood vessels tighten. Because they attack the problem from two different angles, their effects add together.

This is a very common and effective combination used by doctors to treat high blood pressure. You should continue taking both as prescribed. To stay safe, stand up slowly from a sitting or lying position to avoid dizziness. Your doctor will likely monitor your blood pressure regularly and may perform occasional blood tests to check your kidney function and potassium levels. Contact your doctor if you feel severely dizzy or unusually tired.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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