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Can I take Amlodipine besilate and Flecainide together?

Drug interaction guide

Taking amlodipine and flecainide together can lead to an increased risk of heart-related side effects, such as an abnormally slow heart rate or a decrease in how effectively the heart pumps blood. This can lead to symptoms like dizziness, fatigue, or swelling in the ankles.

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Why this happens

Both medications affect the electrical activity and the muscle contractions of the heart. Amlodipine is a calcium channel blocker that relaxes blood vessels, while flecainide is an anti-arrhythmic that controls heart rhythm. When used together, their effects can add up (additive effect), potentially slowing the heart rate too much or weakening the heart's pumping force.

You should use this combination with caution. Your doctor should monitor your heart function and blood pressure regularly, especially when starting the treatment or changing doses. If you experience shortness of breath, extreme tiredness, dizziness, or swelling in your legs, contact your doctor immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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