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Can I take Amlodipine and Perindopril together?

Drug interaction guide

Taking amlodipine and perindopril together can cause your blood pressure to drop lower than if you took either medicine alone. While this is often the goal of treatment, it can sometimes lead to side effects like dizziness, lightheadedness, or fainting, especially when you first start the combination or when your dose is increased. It may also increase the risk of your kidneys not working as well as they should or cause high levels of potassium in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the muscles in your blood vessel walls, while perindopril blocks a hormone that causes blood vessels to tighten. Because they attack the problem from two different angles, their effects add together (an additive effect).

This is a very common and effective combination for treating high blood pressure, and many people take them together in a single 'combination' pill. You should monitor your blood pressure regularly at home. To avoid dizziness, try to get up slowly from a sitting or lying position. If you feel very dizzy, faint, or notice a change in how often you urinate, contact your doctor. Your doctor will likely perform regular blood tests to check your kidney function and potassium levels.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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