Can I take Amizis and Sizopin together?

Why this happens

Both drugs (amisulpride and clozapine) work on the central nervous system and have 'additive' effects, meaning they double up on side effects like sedation. They can both prolong the 'QT interval' (the time it takes for your heart to recharge between beats). Additionally, both carry risks of suppressing bone marrow function, which is where your body makes white blood cells.

You must speak to your doctor before taking these together. This combination is usually only prescribed by specialists under very close supervision. You will need regular blood tests to check your white blood cell count and may need heart tracings (ECGs) to monitor your heart rhythm. Seek immediate medical help if you develop a fever, sore throat, or unusual bruising.

Agranulocytosis (low white blood cell count)

This medicine can cause a life-threatening drop in white blood cells. You MUST have regular blood tests to monitor your immune system. If you develop a fever, sore throat, or any flu-like symptoms, contact your doctor immediately.

Myocarditis (heart muscle inflammation)

This medicine can cause serious heart inflammation, especially in the first two months. Seek urgent medical help if you experience a fast or irregular heartbeat, chest pain, or shortness of breath.

Severe constipation (Gastrointestinal hypomotility)

This medicine can severely slow down your bowel movements, which can lead to life-threatening complications. You must tell your doctor immediately if you become constipated or have difficulty passing wind.

Alcohol

Alcohol can increase the sedative effects of this medicine, making you feel very drowsy and increasing the risk of falls or accidents. It may also increase the risk of serious side effects like breathing difficulties.

Caffeine (Coffee, Tea, Cola, Energy drinks)

Caffeine can significantly increase the levels of this medicine in your blood, which may lead to more side effects. Conversely, if you suddenly stop or reduce your caffeine intake, the levels of the medicine may drop, making it less effective. Try to keep your caffeine intake consistent and talk to your doctor before making any big changes.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.