Can I take Amitriptyline and Magnesium together?

Why this happens

Magnesium can physically bind to amitriptyline in the digestive tract or change the acidity of the stomach, which slows down or reduces the amount of medicine that enters your bloodstream. There is also a slight overlap in side effects, as both can affect the nervous system.

It is generally safe to take both, but you should space them out. Take your amitriptyline at least 2 hours before or 4 to 6 hours after taking a magnesium supplement. If you notice your mood worsening or your pain increasing, or if you feel excessively sleepy, speak to your doctor or pharmacist.

Heart conditions (e.g. arrhythmia, recent heart attack)

Amitriptyline can affect your heart rhythm. You must not take it if you have recently had a heart attack or have certain heart rhythm disorders (like heart block).

Kidney disease

If you have severe kidney problems, magnesium can build up to toxic levels in your blood. Additionally, amitriptyline requires careful monitoring as it is processed by the kidneys.

Glaucoma (specifically acute angle-closure)

Amitriptyline can increase the pressure inside your eye. Do not use this medication if you have acute angle-closure glaucoma, as it can trigger a medical emergency.

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.

Caffeine (Coffee, Tea, Energy Drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen this effect and may also interfere with the sedative effect of the medicine, making it harder to sleep.

Large meals/High-fat foods

Taking magnesium supplements on an empty stomach can sometimes cause diarrhoea or stomach upset. Taking it with a meal can help prevent this, but avoid very high-fat meals which may reduce how much magnesium your body absorbs.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.