Can I take Amitriptyline and Buspirone together?

Why this happens

Both medicines increase the levels of a chemical called serotonin in your brain. If these levels get too high, it can cause 'serotonin syndrome'. Additionally, both drugs have a calming effect on the central nervous system, which can lead to increased sleepiness when combined.

You should only take these two medicines together if they have been specifically prescribed by your doctor. If you are taking both, watch out for symptoms like extreme shivering, sweating, a very fast heartbeat, muscle stiffness, or confusion. If you notice these, seek medical help immediately. Avoid driving or using machinery until you know how this combination affects you.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.