Can I take Am and Edoxaban together?

Why this happens

Edoxaban is moved out of the body by a 'pump' protein called P-glycoprotein. Amiodarone blocks this pump, which means less edoxaban is removed and the levels in your bloodstream rise.

You must inform your doctor if you are taking both. In many cases, the dose of edoxaban needs to be reduced (usually to 30mg instead of 60mg) when taken with amiodarone to prevent the risk of bleeding. Watch for signs of unusual bleeding or bruising and seek medical advice if they occur.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.