Can I take Am and Butec together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Both of these medicines can make you feel very sleepy, dizzy, and unsteady on your feet. Taking them together significantly increases the risk of breathing problems (slow or shallow breathing), extreme drowsiness, and accidental falls.
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Why this happens
Both medications act as central nervous system (CNS) depressants. Amitriptyline is a tricyclic antidepressant and Butec (buprenorphine) is an opioid painkiller. When used together, their sedative effects add up, which can slow down brain activity and the body's urge to breathe.
What you should do
Back to contentsYou must speak to your doctor before taking these together. If your doctor has prescribed both, they will likely start you on the lowest possible doses. Do not drive or operate machinery until you know how these affect you. Seek urgent medical help if you experience extreme sleepiness, confusion, or difficulty breathing.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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