Can I take Allergan and Abilify together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can make you feel very sleepy, dizzy, or confused. It can also make it harder to concentrate or perform tasks that require alertness. In some cases, it may increase the risk of 'anticholinergic' side effects, such as a dry mouth, blurred vision, constipation, or difficulty passing urine.
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Why this happens
Both medicines affect the central nervous system. Allergan (diphenhydramine) is a sedating antihistamine, and Abilify (aripiprazole) is an antipsychotic. When used together, their calming (sedative) effects add up. Additionally, both drugs can block a chemical in the body called acetylcholine, which leads to drying side effects.
What you should do
Back to contentsYou should speak to your doctor before taking these two medicines together. If your doctor confirms you can take both, avoid drinking alcohol and do not drive or operate machinery, as your coordination and reaction times will be significantly slowed. It is illegal to drive if your driving is impaired by any medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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