Can I take Alendronic acid and Apixaban together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking alendronic acid and apixaban together can increase your risk of developing irritation, inflammation, or ulcers in your food pipe (oesophagus) and stomach. If these ulcers occur, apixaban (a blood thinner) may cause them to bleed more severely.
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Why this happens
Alendronic acid is known to be very irritating to the lining of the digestive tract. Apixaban prevents blood clots, which means if the alendronic acid causes any small cuts or ulcers in the stomach or food pipe, they are much more likely to bleed and will be harder for the body to heal.
What you should do
Back to contentsYou can take both, but you must follow the instructions for alendronic acid very strictly: take it first thing in the morning with a full glass of plain water, stay upright (sitting or standing) for at least 30 minutes, and do not eat anything during this time. If you develop any new indigestion, heartburn, pain when swallowing, or if you notice black, tarry stools, contact your doctor immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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