Can I take Accrete d3 and Levothyroxine together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking Accrete D3 at the same time as levothyroxine can significantly reduce the amount of thyroid hormone your body absorbs. This can make your levothyroxine less effective, potentially leading to symptoms of an underactive thyroid, such as tiredness, weight gain, and feeling cold.
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Why this happens
Accrete D3 contains calcium carbonate. Calcium can bind to levothyroxine in the stomach and intestines, forming a complex that the body cannot absorb into the bloodstream.
What you should do
Back to contentsYou must separate the doses of these two medicines. Take your levothyroxine first thing in the morning on an empty stomach, at least 30 to 60 minutes before breakfast. Wait at least 4 hours after taking your levothyroxine before taking your Accrete D3.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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