Can I take Abilify and Bupropion together?

Why this happens

Your liver uses a specific enzyme (called CYP2D6) to break down Abilify and remove it from your body. Bupropion blocks this enzyme. Because the 'cleanup crew' in your liver is blocked, Abilify builds up to much higher levels than intended.

You must speak to your doctor before taking these together. If your doctor decides you need both, they will usually need to reduce your dose of Abilify (often by half). Contact your doctor immediately if you notice unusual muscle movements, severe drowsiness, or feel very restless. Do not stop taking either medication without medical advice.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.