Can I take 3.75 and Msm together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
There is no known direct interaction between Zopiclone and MSM. However, MSM may have a very mild blood-thinning effect in some people, and Zopiclone can occasionally cause dizziness or unsteadiness. Taking them together is unlikely to cause problems for most people, but you should be aware of how you feel when starting them together.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Zopiclone is a sedative that works on the central nervous system to help you sleep. MSM (Methylsulfonylmethane) is a dietary supplement often used for joint pain. They are processed by different pathways in the body and do not share the same chemical targets.
What you should do
Back to contentsIt is generally considered safe to take these together. However, always take Zopiclone exactly as prescribed by your doctor, usually right before bed. If you notice unusual bruising or increased drowsiness the next day, speak with your pharmacist or GP. Always inform your doctor about all supplements you are taking.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Folitrax and Hqtor together?
Taking Folitrax (methotrexate) and Hqtor (hydroxychloroquine) together can increase the risk of side effects, particularly those affecting the liver. However, these two medicines are very commonly prescribed together by specialists to treat conditions like rheumatoid arthritis. While they work well as a team to control inflammation, they require careful monitoring.
Treatment and medication
Can I take Abilify and Fluoxetine together?
Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.