Can I take 20ug h transdermal and Metformin together?
Drug interaction guide
Originally published 14 Mar 2026
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Buprenorphine (the active ingredient in your 20 microgram/hour patch) may interfere with how well metformin controls your blood sugar levels. This could lead to higher blood sugar levels than usual. Additionally, both medications can cause side effects like nausea, vomiting, or drowsiness, which may be more noticeable when taken together.
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Why this happens
Opioid medications like buprenorphine can sometimes affect the body's ability to manage glucose (sugar) and may reduce the effectiveness of diabetes medications like metformin. There is also an additive effect where the stomach-related side effects of both drugs combine.
What you should do
Back to contentsYou should monitor your blood sugar levels more frequently when starting or changing the dose of your buprenorphine patches. If you notice your blood sugar readings are consistently high, or if you feel unusually thirsty or tired, contact your doctor. It is best to avoid or strictly limit alcohol while using these medications, as alcohol can increase the risk of side effects and affect blood sugar control.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.

Treatment and medication
Can I take Levothyroxine and Ramipril together?
There is no direct interaction between levothyroxine and ramipril. However, if your thyroid levels are not well-controlled, it can affect how well your blood pressure medication works.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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