Can I take 2.5mg and Codeine bp together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can cause extreme sleepiness, shallow or slow breathing, and dizziness. In severe cases, it can lead to a deep sleep from which you cannot be woken (coma) or can be life-threatening.
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Why this happens
Both medicines act on the central nervous system to slow down brain activity. Diazepam is a benzodiazepine (sedative) and codeine is an opioid (painkiller). When used together, their sedative effects add up, significantly increasing the risk of respiratory depression (dangerously slow breathing).
What you should do
Back to contentsYou must speak to your doctor before taking these medicines together. They should only be prescribed together if there are no other options. If your doctor does prescribe both, they should use the lowest doses possible for the shortest time. Seek emergency medical help immediately if you experience extreme sleepiness, breathing difficulties, or if a person taking these medicines becomes unresponsive.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Abilify and Fluoxetine together?
Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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