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Can I take 10 and Venladex together?

Drug interaction guide

Taking these two medicines together significantly increases the risk of a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or shivering. In severe cases, it can be life-threatening.

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Why this happens

Both medications work by increasing the levels of serotonin in the brain. Tramadol (the active ingredient in Marol) and venlafaxine (the active ingredient in Venladex) both prevent the reabsorption of serotonin. When used together, they can cause serotonin levels to rise to dangerous levels.

You should not take these two medicines together unless specifically instructed and closely monitored by your doctor. If you are already taking both and feel unwell, or if you experience any of the symptoms mentioned above, seek medical help immediately. Your doctor may suggest an alternative painkiller that does not interact with your antidepressant.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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