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Can I take 0.35mg and Phenylephrine together?

Drug interaction guide

Taking these two medicines together can cause a sudden and dangerous rise in blood pressure. This can lead to symptoms like a severe headache, chest pain, or heart palpitations.

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Why this happens

Phenylephrine works by narrowing blood vessels to clear a blocked nose. Progestogen-only pills (like the 0.35mg 'mini-pill') can sometimes make the body more sensitive to medicines that raise blood pressure. When combined, the effect on your blood vessels and heart rate is much stronger than usual.

You should avoid taking oral phenylephrine (often found in cold and flu remedies) while taking this contraceptive pill. Speak to a pharmacist or doctor about safer alternatives for congestion, such as saline nasal sprays or steam inhalation. If you have already taken both and feel unwell, seek medical advice immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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