Enfermedad cardiovascular
Atheroma
Revisado por pares por Dr Krishna Vakharia, MRCGPÚltima actualización por Dr Colin Tidy, MRCGPLast updated 13 Jun 2023
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Cardiovascular diseases (CVD) is a general term to describe diseases of the heart or blood vessels. The cause of most cardiovascular disease is a build-up of atheroma - a fatty deposit within the inside lining of arteries.
The blood flow to the heart muscle may also be restricted by a blood clot in an artery taking blood to the heart muscle (coronary artery disease). Atheroma or a blood clot may also restrict or prevent blood going to the brain (enfermedad cerebrovascular) or to the legs and feet (enfermedad arterial periférica).
There are lifestyle factors that can be taken to reduce the risk of forming atheroma. These include not smoking; choosing healthy foods; a low salt intake; regular physical activity; keeping your weight and waist size down; drinking alcohol in moderation.
Your blood pressure and cholesterol level are also important. All people aged over 40 years should have a cardiovascular health risk assessment - usually available at your GP surgery. If you have a high risk of developing a cardiovascular disease, treatment to reduce high blood pressure (hypertension) and/or cholesterol may be advised.
At a glance
Cardiovascular disease affects the heart or blood vessels.
It is caused by fatty material called atheroma building up inside arteries.
Symptoms depend on the affected body part, such as chest pain for heart arteries.
Risk factors include smoking, inactivity, obesity, and high blood pressure.
Quitting smoking is often the most effective step to reduce risk.
Maintaining a healthy lifestyle is key for prevention and treatment.
A doctor can calculate your personal cardiovascular health risk.
En este artículo:
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What is a cardiovascular disease?
What is cardiovascular disease?
A cardiovascular disease is a disease of the heart or blood vessels. Narrowing of the blood vessels can lead to cardiovascular diseases. CVD includes coronary heart disease (for example, angina, ataque al corazón y insuficiencia cardíaca), cerebrovascular disease (ataques isquémicos transitorios y accidente cerebrovascular), and enfermedad arterial periférica.
See also the leaflet on Anatomía del corazón y los vasos sanguíneos for more information.
How does an atheroma form?
Volver al contenidoAn atheroma is a fatty material that builds up inside your arteries. Atheromas form wherever the inner lining (endothelium) of the artery walls becomes damaged. An atheroma then grows over time.
An atheroma is made of many substances that circulate in your blood, such as blood cells, calcium, cholesterol and other fats, inflammatory cells and proteins.
Foam cells are a type of cell (macrophage) that localise to fatty deposits on artery walls, where they take in cholesterol, giving them a foamy appearance. These cells make various substances that are involved in the growth of the atheroma. When a foam cell dies, it promotes inflammation of the artery wall and further contributes to cardiovascular disease.
As they grow, atheromas gradually take up more space inside your artery, leaving less room for blood to flow. Depending on where the atheroma is, this may lead to coronary artery disease (eg, angina or heart attack), peripheral artery disease, or a stroke. An atheroma may also rupture and cause a blood clot to form. The clot may block blood flow at that spot, or travel in the blood stream to another site, and block the blood flow there.
An atheroma is more commonly known as atherosclerotic plaque (or just called a plaque).
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Cardiovascular disease symptoms
Volver al contenidoMinor blockage of an artery may not cause any symptoms. Any symptoms will depend on which part of the body is affected by cardiovascular disease, such as:
Blockage of an artery in the heart (coronary artery) may cause dolor de pecho por angina, a ataque al corazón o insuficiencia cardíaca.
Blockage of an artery leading to the brain may cause a accidente cerebrovascular o ataque isquémico transitorio.
Blockage of an artery leading to the leg may cause leg pain with walking (intermittent claudication) or, if more severe, may cause loss of blood supply to the leg and gangrene.
Cardiovascular disease risk factors
Volver al contenidoEverybody has some risk of developing small fatty lumps called atheroma. However, certain risk factors increase the risk. Risk factors include:
Lifestyle risk factors that can be prevented or changed:
Treatable or partly treatable risk factors:
Enfermedad renal crónica causing diminished kidney function.
Fixed risk factors - ones that you cannot alter:
A strong family history. This means if you have a father or brother who developed heart disease or a stroke before they were 55; or, if you have a mother or sister who developed heart disease or a stroke before they were 65.
Being male.
Edad. The older you become, the more likely you are to develop atheroma.
Grupo étnico. For example, people who live in the UK with ancestry from India, Pakistan, Bangladesh, or Sri Lanka have an increased risk.
However, if you have a fixed risk factor, you may want to make extra effort to tackle any lifestyle risk factors that can be changed.
Nota: some risk factors are more risky than others. For example, smoking probably causes a greater risk to health than obesity does. Also, risk factors interact. So, if you have two or more risk factors, your health risk is much more increased than if you just have one.
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How to prevent cardiovascular disease
Volver al contenidoThe following lifestyle risk factors should be changed to help prevent cardiovascular disease.
Dejar de fumar
Lifetime fumar roughly doubles your risk of developing heart disease. The chemicals in tobacco get into the bloodstream from the lungs. They damage the blood vessels (arteries) and other parts of the body. Your risk of having a stroke and of developing other diseases such as lung cancer is also increased.
Stopping smoking is often the single most effective thing that a person can do to reduce their health risk. The increased risk falls rapidly after stopping smoking (although it takes a few years before the excess risk reduces completely). If you smoke and are having difficulty in stopping then see your practice nurse for help and advice.
Being physically active
People who are physically active have a lower risk of developing cardiovascular diseases compared with inactive people. To gain health benefits you should do at least 30 minutes of moderate physical activity, on most days (at least five days per week).
30 minutes in a day is probably the minimum to gain health benefits. However, you do not have to do this all at once. For example, cycling to work and back 15 minutes each way adds up to the total of 30 minutes.
Moderate physical activity means that you get warm, mildly out of breath, and mildly sweaty. For example, brisk walking, jogging, swimming, cycling, etc. However, research studies do suggest that the more vigorous the exercise, the better for health - particularly for preventing heart disease.
On most days. You cannot store up the benefits of physical activity. You need to do it regularly.
Perder peso
If you are overweight, you are more likely to develop cardiovascular diseases, diabetes, or certain cancers. People with type 2 diabetes have a higher risk of cardiovascular disease. The increased health risk of obesity is most marked when the excess fat is mainly in the tummy (abdomen) rather than on the hips and thighs. As a rule, a waist measurement of 102 cm or above for men (92 cm for Asian men) and 88 cm or above for women (78 cm for Asian women) is a significant health risk.
Improving diet
Eating healthily helps to control obesity and lower your cholesterol level. Both of these help to reduce your health risk. Also, there is some evidence that eating oily fish (herring, sardines, mackerel, salmon, kippers, pilchards, atún tuna, etc) helps to protect against heart disease.
It is probably the omega-3 fatty acids in the fish oil that help to reduce the build-up of small fatty lumps called atheroma. Also, fruit and vegetables, as well as being low in fat, also contain antioxidants and vitamins which may help to prevent atheroma from building up. Briefly, a healthy diet means:
AT LEAST five portions, or ideally 7-9 portions, of a variety of fruit and vegetables per day.
A THIRD OF MOST MEALS should be starch-based foods (such as cereals, wholegrain bread, potatoes, rice, pasta), plus fruit and vegetables.
NOT MUCH fatty food such as fatty meats, cheeses, full-cream milk, fried food, butter, etc. Use low-fat, mono-unsaturated or polyunsaturated spreads. One study conducted at Harvard University found that replacing saturated fats with polyunsaturated fats is an effective way of lowering your risk of heart attacks and other serious problems from heart disease.
INCLUDE 2-3 portions of fish per week, at least one of which should be oily (such as herring, mackerel, sardines, kippers, salmon, or atún tuna).
LIMIT SALT to no more than 5 g a day (and less for children). See below for details.
If you eat meat, it is best to eat lean meat, or poultry such as chicken.
Si fríes, elige un aceite vegetal como el de girasol, colza u oliva.
Following a Mediterranean diet can reduce the chance of developing cardiovascular disease. See the separate leaflet called Mediterranean Diet.
Reducing salt intake
Adults should eat no more than 5 g of salt a day. This is about a teaspoon of salt. Even a modest reduction in intake can make quite a big difference. The current average daily intake of salt in the UK is 9 g per day.
About three quarters of the salt we eat is already in the foods we buy. Simply checking food labels and choosing foods with lower salt options can make a big difference. A tip: sodium is usually listed on the food label. Multiplying the sodium content by 2.5 will give the salt content. Also, try not to add salt to food at the table.
Cutting down alcohol
Drinking a small or moderate amount of alcohol probably reduces the risk of developing cardiovascular diseases (38% compared with teetotallers in one study). That is, 1-2 units per day - which is up to 14 units per week. Drinking more than the recommended upper limits can be harmful. Men and women should drink no more than 14 units per week.
Cardiovascular disease treatment
Volver al contenidoThe treatment of cardiovascular disease includes:
Lifestyle measures, including:
Some medicines may be used to treat risk factors of cardiovascular disease, such as presión arterial alta, colesterol alto o diabetes.
Additional treatment may be needed depending on the type and severity of cardiovascular disease. See also the leaflets on coronary heart disease (angina, ataque al corazón y insuficiencia cardíaca), cerebrovascular disease (ataques isquémicos transitorios y accidente cerebrovascular), and peripheral arterial disease.
Calculating your cardiovascular health risk
Volver al contenidoA 'risk factor calculator' is often used by healthcare professionals. This can assess your cardiovascular health risk. A score is calculated which takes into account all your risk factors such as age, sex, smoking status, blood pressure, cholesterol level, etc.
The calculator has been devised after a lot of research that monitored thousands of people over a number of years. The score gives a fairly accurate indication of your risk of developing a cardiovascular disease over the next 10 years. See the separate leaflet called Cardiovascular Health Risk Assessment.
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Preguntas frecuentes
What parts of the body are affected by cardiovascular disease?
Cardiovascular disease can affect various parts of the body. Blockages in arteries within the heart can lead to angina chest pain, a heart attack, or heart failure. If an artery leading to the brain is blocked, it might cause a stroke or transient ischaemic attack. Blockage of an artery supplying the leg can result in leg pain when walking (intermittent claudication), or, in severe cases, loss of blood supply and gangrene.
How does smoking increase my risk of developing heart disease?
Smoking roughly doubles your risk of developing heart disease. The chemicals present in tobacco enter your bloodstream from your lungs and damage your blood vessels, which are arteries, and other parts of your body. Smoking also increases your risk of having a stroke and developing other diseases such as lung cancer.
If I am overweight, where is the fat most risky for my cardiovascular health?
The increased health risk from obesity is most pronounced when the excess fat is mainly located in the tummy area (abdomen), rather than on the hips and thighs. For men, a waist measurement of 102 cm or more (or 92 cm for Asian men) is considered a significant health risk. For women, this measurement is 88 cm or more (or 78 cm for Asian women).
What kind of fats are best to include in my diet to protect my heart?
To protect your heart, it's advised to limit fatty foods such as fatty meats, cheeses, full-cream milk, fried food, and butter. Instead, use low-fat, mono-unsaturated or polyunsaturated spreads. Replacing saturated fats with polyunsaturated fats is an effective way to lower your risk of heart attacks and other serious heart problems. Additionally, eating oily fish (like herring, sardines, mackerel, salmon, kippers, pilchards, fresh tuna) is beneficial, likely due to the omega-3 fatty acids they contain, which help reduce the build-up of fatty lumps called atheroma.
How much salt should I aim to eat daily?
Adults should aim to consume no more than 5 grams of salt a day, which is about one teaspoon. Even a small reduction in salt intake can make a significant difference. Most of the salt we eat (about three-quarters) is already in the foods we buy, so checking food labels and selecting lower-salt options can be very helpful. You can also try not to add extra salt to your food at the table.
The article mentions a 'risk factor calculator'. What is that and how does it work?
A 'risk factor calculator' is a tool frequently used by healthcare professionals to assess your cardiovascular health risk. It calculates a score by considering various risk factors such as your age, sex, smoking status, blood pressure, and cholesterol level. This calculator is based on extensive research involving thousands of people over many years and provides a fairly accurate indication of your risk of developing a cardiovascular disease over the next 10 years.
Lecturas adicionales y referencias
- Cardiovascular disease prevention; NICE Public Health Guideline (June 2010)
- Risk estimation and the prevention of cardiovascular disease; Scottish Intercollegiate Guidelines Network - SIGN (2017)
- CVD risk assessment and management; NICE CKS, mayo 2023 (acceso solo en el Reino Unido)
- Cardiovascular risk assessment and lipid modification; NICE Quality standard, May 2023
- Enfermedad cardiovascular: evaluación y reducción del riesgo, incluyendo la modificación de lípidos; Guía Clínica NICE (julio 2014 - última actualización mayo 2023) Reemplazada por NG238
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About the authorView full bio

Dr Colin Tidy, MRCGP
Médico General, Autor Médico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
About the reviewerView full bio

Dr Krishna Vakharia, MRCGP
Chief Medical Officer for Health, Optum UK
MBChB, MRCGP(2013), BMedSci (hons), DFSRH, DRCOG, PGDipDerm (Distn)
La Dra. Krishna Vakharia es una médica general del NHS. También es examinadora habitual del Diploma de Posgrado en Dermatología Práctica en la Universidad de Cardiff, además de ser la Directora Médica de salud en Optum UK.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Next review due: 11 Jun 2028
13 Jun 2023 | Última versión

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