Reemplazo de heroína con metadona
Revisado por pares por Prof. Cathy Jackson, MRCGPÚltima actualización por Dra. Mary Harding, MRCGPÚltima actualización 18 Jul 2018
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En esta serie:Drogas recreativasTratamiento de la dependencia de drogasReemplazo de heroína por buprenorfina
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Si dejas de consumir heroína, la metadona puede prevenir o reducir los desagradables síntomas de abstinencia. Muchas personas permanecen en tratamiento con metadona a largo plazo. Sin embargo, algunas personas reducen gradualmente la dosis y dejan las drogas por completo. No debes consumir drogas callejeras ni mucho alcohol cuando estás tomando metadona.
De un vistazo
Methadone is a prescribed medicine used to prevent heroin withdrawal symptoms.
It lasts longer than heroin, helping people move away from street drugs.
A doctor will assess you including your health, drug use, and may do tests.
Dosage starts low and is slowly increased to prevent withdrawal symptoms safely.
Most people stay on methadone long-term, which is called maintenance.
Do not stop taking methadone suddenly, especially if pregnant.
Always keep methadone out of reach of children.
What is heroin addiction?
If you are addicted to heroin it means that you develop withdrawal symptoms within a day or so of the last dose. These symptoms are listed in the separate leaflet called Medicines for Drug Dependence. If you are addicted to heroin, you need a regular dose to feel 'normal'.
What is methadone?
Metadona is a drug that is similar to heroin, although it lasts a lot longer in the body. It can be prescribed. If you take methadone, you are unlikely to develop withdrawal symptoms if you stop heroin (or the withdrawal symptoms are much less severe). If you take methadone under supervision from a doctor instead of street heroin, you are:
More likely to be able to get away from the street 'drug scene'.
Likely to feel better in yourself.
More likely to be able to get off drugs for good.
Who prescribes methadone, and when?
A typical plan
Most GPs will refer you to a community drug team to be assessed. Following assessment, a member of the community drug team will usually contact your GP quite quickly to recommend a dose of methadone and a plan for follow-up. Some GPs who are specially trained may assess some cases and prescribe without the need for referral.
Evaluación
This usually includes:
Taking details of your health and social circumstances.
Taking details of your past and current drug taking and whether methadone is needed or appropriate.
An examination.
A urine test (or a mouth swab test) to confirm the drugs you are taking.
An assessment of what you think you need at this present time.
If you have been injecting drugs such as heroin, it is also common to advise:
A blood test which includes testing for HIV, checking the health of your liver (liver function tests) and checking for hepatitis B and hepatitis C.
Immunisation against hepatitis A, hepatitis B y tétanos (if not previously immunised).
If appropriate, immunisation against hepatitis B for your partner and children.
About the dangers of injecting, about the dangers of using shared needles and syringes and on other ways to reduce harm to yourself.
Starting off with methadone
Methadone is usually started some time after assessment when the results of the urine test are back. An initial dose is chosen. The aim is to prevent withdrawal symptoms. However, methadone can cause serious harm, or death, in overdose. Therefore, at first your doctor will prescribe a low-ish dose to 'play safe' and see you frequently to adjust the dose. Be patient, this early stage is very important. The initial dose is usually gradually increased to a regular maintenance dose. But note:
Methadone takes 2-4 hours to reach its peak effect level in the blood. However, the time it takes to produce its maximum effect can vary from person to person.
Methadone accumulates in your body. So, you will feel a greater effect of the drug over a few days even without increasing the dose.
It may take a few weeks to get to the correct dose which prevents all withdrawal symptoms.
Try to accept that you may have some, or partial, withdrawal symptoms until the correct dose is found. The correct dose varies from person to person, depending on how much heroin you were using and how your body deals with (metabolises) the methadone. You should not take any street drugs or much alcohol when you are on methadone.
Maintenance and coming off ('detox')
Once established on a regular dose, most people stay on methadone for a long time or even long-term. This is called maintenance and helps you to keep off street drugs. Some people gradually reduce the dose and come off it. This is called detoxification, or 'detox'. However, it usually takes months and sometimes years before most people are ready to consider 'detox'. It is often safer to stay on methadone than to 'detox' before you are ready.
Taking methadone
Methadone is usually prescribed as a once-daily dose in liquid form. You will usually be asked to take it under the supervision of the pharmacist who dispenses the methadone to you. This means there can be no doubt about how much methadone you take at each dose. This supervision may be relaxed after a few months of you taking a regular maintenance dose.
Nota importante: it is essential that you take the methadone regularly. If you miss three or more daily doses your body may lose its ability to break down the drug (tolerance). You can still continue with the withdrawal programme but you may need to start again with a lower dose.
Some other points about taking methadone
You are more likely to succeed in staying off heroin if you have support and counselling during this difficult time. This may be from a local drug community team (or similar). Self-help groups or other agencies may also be of help. It is much harder to 'do it alone' - so do go for counselling and help if it is available in your area.
Some prescribed medicines may interfere with methadone - for example, some used to treat tuberculosis (TB) y epilepsia. Tell the doctor who prescribes methadone if you are taking any other medicines. However, most prescribed medicines can be taken in the normal way.
Other street drugs, como benzodiazepinas ('benzos'), and alcohol, can affect methadone. It is best not to take any other drugs and not to drink too much alcohol.
You will be asked to give a urine sample from time to time by your doctor.
Conducción. If you use heroin, methadone or similar drugs, you should tell the DVLA. You are likely to be banned from driving. However, if you are on a supervised methadone programme, you may be allowed to drive again subject to an annual medical review.
Embarazo. If you become pregnant you should not suddenly stop your methadone withdrawal programme. It is riskier to stop methadone suddenly in the first three months of pregnancy than to continue on your regular dose. Many women choose to withdraw from methadone during pregnancy and this is best done during the third to sixth month of pregnancy (the 'second trimester'). Your doctor will advise.
Keep methadone and any other drugs out of reach of children.
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Preguntas frecuentes
What is the typical time frame for the assessment process before starting methadone?
The article states that a member of the community drug team will usually contact your GP quite quickly to recommend a dose of methadone and a follow-up plan after assessment. However, methadone is usually started some time after assessment, specifically when the results of the urine test are available. This suggests the initial assessment may be followed by a waiting period for test results before treatment begins.
If I am pregnant, can I continue my methadone treatment, and if I want to stop, when is the best time?
If you are pregnant, you should not suddenly stop your methadone withdrawal programme. Stopping methadone abruptly in the first three months of pregnancy carries more risk than continuing your regular dose. If you choose to withdraw from methadone during pregnancy, the safest time to do so is typically during the third to sixth month (the second trimester). Your doctor will provide specific advice.
What happens if I miss several doses of methadone?
If you miss three or more daily doses of methadone, your body may lose its ability to tolerate the drug as it usually does. You can still continue with your withdrawal programme, but you might need to restart at a lower dose to safely adjust.
How quickly will I feel the effects of methadone after taking a dose?
Methadone typically takes between 2 to 4 hours to reach its peak effect level in the blood. However, the exact time it takes to produce its maximum effect can vary from person to person. Additionally, methadone accumulates in your body, meaning you will feel a greater overall effect of the drug over a few days, even if the dose remains the same.
What support is available to help me stay off heroin while on methadone?
You are more likely to succeed in staying off heroin if you receive support and counselling during this challenging period. This support can come from a local drug community team or similar services. Self-help groups and other agencies may also be beneficial. It is much more difficult to manage alone, so it is advised to seek counselling and help if it is available in your area.
Lecturas adicionales y referencias
- Uso indebido de drogas en mayores de 16 años: desintoxicación de opioides; Guía Clínica NICE (Julio 2007)
- Roux P Dr, Michel L Dr, Cohen J, et al; Initiation of Methadone in primary care (ANRS-Methaville): a phase III randomized intervention trial. BMC Public Health. 2012 Jun 28;12(1):488.
- Evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP; British Association for Psychopharmacology (May 2012)
- Dependencia a los opioides; NICE CKS, April 2015 (UK access only)
- Nielsen S, Larance B, Degenhardt L, et al; Opioid agonist treatment for pharmaceutical opioid dependent people. Cochrane Database Syst Rev. 2016 May 9;(5):CD011117. doi: 10.1002/14651858.CD011117.pub2.
- Bart G; Maintenance medication for opiate addiction: the foundation of recovery. J Addict Dis. 2012;31(3):207-25. doi: 10.1080/10550887.2012.694598.
- Clinical Guidelines on Drug Misuse and Dependence Update; Independent Expert Working Group Drug misuse and dependence: UK guidelines on clinical management. London: Dept of Health (July 2017)
- Saulle R, Vecchi S, Gowing L; Supervised dosing with a long-acting opioid medication in the management of opioid dependence. Cochrane Database Syst Rev. 2017 Apr 27;4:CD011983. doi: 10.1002/14651858.CD011983.pub2.
Sobre el autorVer biografía completa

Dr Mary Harding, MRCGP
Médico General, Autor Médico
BA, MA, MB, BChir, MRCGP, DFFP
La Dra. Mary Harding se graduó de la facultad de medicina de la Universidad de Cambridge en 1989.
Acerca del revisorVer biografía completa

Prof. Cathy Jackson, MRCGP
Autor Médico
BSc (Hons) Fisiología, MB, ChB, MRCGP, MD
La profesora Cathy Jackson se graduó de la Escuela de Medicina de Manchester, habiendo obtenido un título con honores de primera clase en fisiología en el camino.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
18 Jul 2018 | Última versión

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