Can I take Prozac and Venlafaxine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Prozac (fluoxetine) and venlafaxine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This occurs when there is too much serotonin in your nervous system. Symptoms can include shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, Prozac can slow down how your body breaks down venlafaxine, leading to higher levels of the drug in your blood and increasing the risk of side effects.
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Why this happens
Both medications increase serotonin levels in the brain (pharmacodynamic interaction). Furthermore, Prozac is a strong inhibitor of the liver enzyme (CYP2D6) responsible for clearing venlafaxine from your system, which can lead to a toxic buildup of venlafaxine (pharmacokinetic interaction).
What you should do
You should not take these two medications together unless specifically instructed and closely monitored by a specialist. If you are currently taking both and experience agitation, hallucinations, a very fast heartbeat, or muscle twitching, seek emergency medical help immediately. Always consult your doctor before making any changes to your antidepressant medication.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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