Can I take Magnesium 5 in one and Progynova together?
Drug interaction guide
Originally published 25 Jan 2026
Satisface las necesidades del paciente directrices editoriales
- DescargarDescargar
- Compartir
- Idioma
- Debate
Taking magnesium supplements at the same time as Progynova (estradiol) may slightly reduce how much of the hormone your body absorbs. This could potentially make your hormone replacement therapy (HRT) less effective.
En este artículo:
Seguir leyendo
Why this happens
Magnesium can bind to certain medications in the digestive tract or change the acidity of the stomach, which can interfere with how well the body absorbs oestrogen.
What you should do
You do not need to stop taking either, but it is best to separate the doses. Take your Progynova at least 2 hours before or 4 to 6 hours after taking your magnesium supplement. If you notice a return of menopause symptoms (like hot flushes), speak to your doctor.
Seguir leyendo
Important precautions
Blood clots and stroke
This medicine significantly increases your risk of developing blood clots (DVT or pulmonary embolism) and stroke. Seek immediate medical help if you experience painful leg swelling, sudden chest pain, or breathlessness.
Severe kidney impairment
If you have severe kidney disease, you must not take magnesium supplements. Your kidneys may not be able to remove excess magnesium from your blood, which can lead to dangerous levels affecting your heart and breathing.
Cáncer de mama
Progynova can stimulate the growth of certain types of breast cancer. You must perform regular breast self-checks and attend all scheduled mammograms while using this treatment.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the levels of estradiol in your blood, which may increase the risk of side effects. It is best to avoid large amounts of grapefruit juice while taking this medicine.
Dairy products (Milk, Cheese, Yoghurt)
Calcium-rich foods like dairy can interfere with how your body absorbs magnesium if taken at the same time. Try to space out your magnesium supplement and dairy intake by at least 2 hours.
Alcohol
Regular or excessive alcohol consumption can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective.
Caffeine (Coffee, Tea, Energy drinks)
High intake of caffeine can have a mild diuretic effect, which may increase the excretion of magnesium from the body.
Seguir leyendo
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Tratamiento y medicación
Can I take Ashwagandha and Oestrogel pump-pack /actuation together?
Ashwagandha may increase the levels of oestrogen in your body, potentially making the effects of your Oestrogel stronger than intended. It might also interfere with how your body naturally balances hormones.

Tratamiento y medicación
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.
Seguir leyendo
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

Pregunte, comparta, conecte.
Explore debates, formule preguntas y comparta experiencias sobre cientos de temas de salud.

¿Se encuentra mal?
Evalúe sus síntomas en línea de forma gratuita
Suscríbase al boletín informativo para pacientes.
Tu dosis semanal de consejos de salud claros y fiables, redactados para ayudarte a sentirte informado, seguro y en control.
Al suscribirte, aceptas nuestra Política de privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.