Can I take Lactulose and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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Lactulose is actually used to treat a side effect caused by Shortec (oxycodone). Shortec is an opioid painkiller that commonly causes constipation. Lactulose is a laxative that helps relieve this. There is no harmful interaction between them; rather, they are often prescribed together for this reason.
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Why this happens
Shortec (oxycodone) slows down the movement of the digestive system. Lactulose works by drawing water into the bowel to soften the stool and stimulate movement, effectively reversing the constipating effect of the painkiller.
What you should do
It is safe and often necessary to take these together. If you are taking Shortec regularly, you should take your lactulose as directed by your doctor to prevent constipation. Ensure you drink plenty of water.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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