Can I take Ibuprofen gel 10% and Ripinrole together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between ibuprofen gel and ropinirole. Ibuprofen gel is applied to the skin, and very little of the medicine reaches your bloodstream compared to taking a tablet. This makes it much less likely to interfere with other medications like ropinirole.
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Why this happens
Ropinirole is processed by a specific liver enzyme (CYP1A2), while ibuprofen is processed by different enzymes (CYP2C9). Because they use different pathways and the amount of ibuprofen absorbed from a gel is very low, they do not interfere with each other's metabolism or effects.
What you should do
It is generally safe to use these two medications together. However, always apply the gel only to the affected area and do not exceed the dose recommended on the packaging. If you notice any new or worsening side effects, such as increased sleepiness or dizziness, mention it to your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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