Can I take Ibuprofen gel 10% and Oxypro together?
Drug interaction guide
Originally published 25 Jan 2026
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Using ibuprofen gel alongside Oxypro (oxycodone) may increase the risk of side effects such as dizziness, drowsiness, and confusion. While the risk is much lower with a gel than with ibuprofen tablets, some of the medicine is still absorbed into your bloodstream. Additionally, both medicines can occasionally cause stomach irritation or, in rare cases, affect kidney function when used together for a long time.
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Why this happens
Oxycodone is an opioid painkiller that slows down the central nervous system. Ibuprofen is an anti-inflammatory (NSAID). When used together, they can have an additive effect on the body, potentially increasing drowsiness. Although the gel is applied to the skin, a small amount enters the system and can interact with the way oxycodone affects the body and the stomach lining.
What you should do
It is generally safe to use these together for short periods, but you should use the ibuprofen gel sparingly. If you feel excessively sleepy, dizzy, or develop stomach pain, stop using the gel and speak to your doctor. Avoid drinking alcohol while using these medicines, as it will make the drowsiness much worse.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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