Can I take Amitriptyline and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
Satisface las necesidades del paciente directrices editoriales
- DescargarDescargar
- Compartir
- Idioma
- Debate
Taking amitriptyline and Shortec (oxycodone) together can make you feel very drowsy, dizzy, and confused. It can also significantly slow down your breathing and heart rate, which can be dangerous. You may also experience increased side effects like a very dry mouth, constipation, and difficulty passing urine.
En este artículo:
Seguir leyendo
Why this happens
Both medicines act on the central nervous system to slow down brain activity. Amitriptyline is a tricyclic antidepressant and Shortec is an opioid painkiller; when used together, their sedative effects add up. Additionally, both drugs have 'anticholinergic' effects, which multiply the risk of side effects like constipation and blurred vision.
What you should do
You should only take these two medicines together if they have been specifically prescribed by your doctor with the knowledge that you are taking both. If you feel excessively sleepy, have shallow breathing, or feel like you might faint, seek medical help immediately. Avoid driving or operating machinery until you know how this combination affects you. Do not drink alcohol while taking these medicines.
Seguir leyendo
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Tratamiento y medicación
Can I take Ibuprofen gel 10% and Shortec together?
Using ibuprofen gel alongside Shortec (oxycodone) is generally safe, but there is a small risk of increased side effects such as drowsiness, dizziness, or stomach irritation if the ibuprofen is absorbed into the bloodstream in significant amounts.

Tratamiento y medicación
Can I take Esomeprazole and Vitamin c together?
Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.
Seguir leyendo
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

Pregunte, comparta, conecte.
Explore debates, formule preguntas y comparta experiencias sobre cientos de temas de salud.

¿Se encuentra mal?
Evalúe sus síntomas en línea de forma gratuita
Suscríbase al boletín informativo para pacientes.
Tu dosis semanal de consejos de salud claros y fiables, redactados para ayudarte a sentirte informado, seguro y en control.
Al suscribirte, aceptas nuestra Política de privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.